If you arrange your page building blocks horizontally with CSS using display: inline-block; property, they will act "responsively" when you change the browser window size to that of a mobile - blocks will drop underneath each other.
Precondition is that all blocks at least have a defined max-width (height does not matter).
Additionally you can mix in float: right; and float: left; properties on the first and last block. These alignments will hold even when the blocks are arranged underneath each other.

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Use a block-element, or CSS clear: both; to continue below the responsive blocks. Another footer span.